Kanserin temelinde DNA\u2019da meydana gelen mutasyonlar\u0131n yer ald\u0131\u011f\u0131n\u0131 belirten Medicana Bursa Hastanesi Genetik Hastal\u0131klar\u0131 De\u011ferlendirme Merkezi\u2019nden Prof. Dr. Sezgin, bu de\u011fi\u015fimlerin iki ana grupta incelendi\u011fini ifade ederek, “Kal\u0131tsal (germline) mutasyonlar anne veya babadan ge\u00e7erek bireyin t\u00fcm h\u00fccrelerinde bulunur ve nesilden nesile aktar\u0131labilir. Somatik mutasyonlar ise ya\u015fam boyunca \u00e7evresel fakt\u00f6rler veya ya\u015flanma sonucu olu\u015fur ve yaln\u0131zca belirli dokularda g\u00f6r\u00fcl\u00fcr” dedi.<\/p>\n
Kanserin art\u0131k tek tip bir hastal\u0131k olarak de\u011ferlendirilmedi\u011fini belirten Sezgin, “Her kanser hastas\u0131 molek\u00fcler d\u00fczeyde kendine \u00f6zg\u00fc bir profile sahiptir. Bu nedenle tedavi yakla\u015f\u0131m\u0131 da ki\u015fiye \u00f6zel olmal\u0131d\u0131r” dedi.<\/p>\n
T\u00fcm\u00f6rden al\u0131nan \u00f6rneklerle yap\u0131lan genetik analizlerin, hastal\u0131\u011f\u0131n nedenini ortaya koydu\u011funu ifade eden Sezgin, \u015fu bilgileri payla\u015ft\u0131:<\/p>\n
“Genetik testler sayesinde kanserin molek\u00fcler alt tipi belirlenir, erken evrede risk tespiti yap\u0131labilir ve \u00f6zellikle baz\u0131 kan hastal\u0131klar\u0131nda tan\u0131 netle\u015ftirilebilir. Ayr\u0131ca ki\u015fiye \u00f6zel tarama programlar\u0131 olu\u015fturmak da m\u00fcmk\u00fcn hale gelir.”<\/p>\n
Kanserlerin yakla\u015f\u0131k y\u00fczde 5 ila 10\u2019unun kal\u0131tsal oldu\u011funu hat\u0131rlatan Sezgin, aile \u00f6yk\u00fcs\u00fcn\u00fcn \u00f6nemine dikkat \u00e7ekerek, “Ailede kanser \u00f6yk\u00fcs\u00fc bulunan bireylerde genetik testler, hastal\u0131k ortaya \u00e7\u0131kmadan riskin belirlenmesini sa\u011flar. Bu sayede erken tarama ve \u00f6nleyici tedbirler planlanabilir. Ayn\u0131 zamanda di\u011fer aile bireylerinin de de\u011ferlendirilmesine imkan tan\u0131r” ifadelerini kulland\u0131.<\/p>\n
Modern onkolojide art\u0131k standart tedavi yakla\u015f\u0131mlar\u0131n\u0131n yerini ki\u015fiselle\u015ftirilmi\u015f t\u0131bb\u0131n ald\u0131\u011f\u0131n\u0131 belirten Sezgin, s\u00f6zlerini \u015f\u00f6yle s\u00fcrd\u00fcrd\u00fc:<\/p>\n
“G\u00fcn\u00fcm\u00fczde bir\u00e7ok kanser t\u00fcr\u00fcnde, belirli genetik mutasyonlar\u0131 hedef alan ak\u0131ll\u0131 ila\u00e7lar kullan\u0131lmaktad\u0131r. Genetik testler, hangi hastan\u0131n hangi tedaviden fayda g\u00f6rece\u011fini g\u00f6steren bir yol haritas\u0131 sunar. B\u00f6ylece gereksiz kemoterapilerden ka\u00e7\u0131n\u0131labilir, en etkili tedaviye h\u0131zl\u0131ca ba\u015flanabilir.”<\/p>\n
Genetik analizlerin, hastal\u0131\u011f\u0131n agresifli\u011fini, metastaz riskini ve tedaviye yan\u0131t\u0131 \u00f6ng\u00f6rmede kritik rol oynad\u0131\u011f\u0131n\u0131 vurgulayan Sezgin, hedefe y\u00f6nelik tedaviler ve imm\u00fcnoterapi se\u00e7iminde de bu testlerin belirleyici oldu\u011funu s\u00f6zlerine ekledi. Prof. Dr. Sezgin, kanserle m\u00fccadelede genetik biliminin sundu\u011fu imkanlar\u0131n her ge\u00e7en g\u00fcn geli\u015fti\u011fini belirterek, “Art\u0131k hastal\u0131\u011f\u0131 de\u011fil, hastay\u0131 tedavi ediyoruz” dedi.<\/p>\n
Kaynak: \u0130HA<\/p>\n","protected":false},"excerpt":{"rendered":"
Kanserin temelinde DNA\u2019da meydana gelen mutasyonlar\u0131n yer ald\u0131\u011f\u0131n\u0131 belirten Medicana Bursa Hastanesi Genetik Hastal\u0131klar\u0131 De\u011ferlendirme…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[],"class_list":["post-7061","post","type-post","status-publish","format-standard","hentry","category-guncel"],"_links":{"self":[{"href":"https:\/\/ruhatv.org\/index.php\/wp-json\/wp\/v2\/posts\/7061","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/ruhatv.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ruhatv.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ruhatv.org\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/ruhatv.org\/index.php\/wp-json\/wp\/v2\/comments?post=7061"}],"version-history":[{"count":0,"href":"https:\/\/ruhatv.org\/index.php\/wp-json\/wp\/v2\/posts\/7061\/revisions"}],"wp:attachment":[{"href":"https:\/\/ruhatv.org\/index.php\/wp-json\/wp\/v2\/media?parent=7061"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ruhatv.org\/index.php\/wp-json\/wp\/v2\/categories?post=7061"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ruhatv.org\/index.php\/wp-json\/wp\/v2\/tags?post=7061"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}